|Antagonist Binds AND Blocks Activation
This prevents exongenous and endogenous agonists from
altering the receptor and the neuron. Generally good antagonists will have a greater binding affinity than agonists.
This allows Narcan to replace opiate and negate its effects
|Agonist Binds AND Activates Receptor
Ion flow is altered, allowing greater or fewer ions into the neuron, increasing or decreasing the probability that the neuron will fire an action potential